Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis
AL Peljto, Y Zhang, TE Fingerlin, SF Ma, JGN Garcia… - Jama, 2013 - jamanetwork.com
Importance Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF),
which are based on clinical and physiological parameters, have modest value in predicting
which patients will progress. In addition to the potential for improving prognostic models,
identifying genetic and molecular features that are associated with IPF mortality may provide
insight into the underlying mechanisms of disease and inform clinical trials. Objective To
determine whether the MUC5B promoter polymorphism (rs35705950), previously reported …
which are based on clinical and physiological parameters, have modest value in predicting
which patients will progress. In addition to the potential for improving prognostic models,
identifying genetic and molecular features that are associated with IPF mortality may provide
insight into the underlying mechanisms of disease and inform clinical trials. Objective To
determine whether the MUC5B promoter polymorphism (rs35705950), previously reported …