[HTML][HTML] Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture
M Sricholpech, I Perdivara, H Nagaoka… - Journal of biological …, 2011 - ASBMB
Lysyl hydroxylase 3 (LH3), encoded by Plod3, is the multifunctional collagen-modifying
enzyme possessing LH, hydroxylysine galactosyltransferase (GT), and
galactosylhydroxylysine-glucosyltransferase (GGT) activities. Although an alteration in type I
collagen glycosylation has been implicated in several osteogenic disorders, the role of LH3
in bone physiology has never been investigated. To elucidate the function of LH3 in bone
type I collagen modifications, we used a short hairpin RNA technology in a mouse …
enzyme possessing LH, hydroxylysine galactosyltransferase (GT), and
galactosylhydroxylysine-glucosyltransferase (GGT) activities. Although an alteration in type I
collagen glycosylation has been implicated in several osteogenic disorders, the role of LH3
in bone physiology has never been investigated. To elucidate the function of LH3 in bone
type I collagen modifications, we used a short hairpin RNA technology in a mouse …