Phenylbutyric acid inhibits epithelial-mesenchymal transition during bleomycin-induced lung fibrosis
H Zhao, HY Qin, LF Cao, YH Chen, ZX Tan, C Zhang… - Toxicology letters, 2015 - Elsevier
A recent report showed that unfolded protein response (UPR) signaling was activated during
bleomycin (BLM)-induced pulmonary fibrosis. Phenylbutyric acid (PBA) is an endoplasmic
reticulum (ER) chemical chaperone that inhibits the UPR signaling. The present study
investigated the effects of PBA on BLM-induced epithelial-mesenchymal transition (EMT)
and pulmonary fibrosis. For induction of pulmonary fibrosis, all mice except controls were
intratracheally injected with a single dose of BLM (3.0 mg/kg). In PBA+ BLM group, mice …
bleomycin (BLM)-induced pulmonary fibrosis. Phenylbutyric acid (PBA) is an endoplasmic
reticulum (ER) chemical chaperone that inhibits the UPR signaling. The present study
investigated the effects of PBA on BLM-induced epithelial-mesenchymal transition (EMT)
and pulmonary fibrosis. For induction of pulmonary fibrosis, all mice except controls were
intratracheally injected with a single dose of BLM (3.0 mg/kg). In PBA+ BLM group, mice …