TET2 and DNMT3A Mutations in Human T-Cell Lymphoma
L Couronné, C Bastard… - New England Journal of …, 2012 - Mass Medical Soc
L Couronné, C Bastard, OA Bernard
New England Journal of Medicine, 2012•Mass Medical SocA substantial fraction of T-cell lymphomas carry mutations in two genes—TET2 and
DNMT3A—that are involved in DNA methylation. The co-occurrence of these mutations
suggests that inhibitors of DNA methylation could possibly have antitumor effects in such
patients.
DNMT3A—that are involved in DNA methylation. The co-occurrence of these mutations
suggests that inhibitors of DNA methylation could possibly have antitumor effects in such
patients.
A substantial fraction of T-cell lymphomas carry mutations in two genes — TET2 and DNMT3A — that are involved in DNA methylation. The co-occurrence of these mutations suggests that inhibitors of DNA methylation could possibly have antitumor effects in such patients.
The New England Journal Of Medicine