Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2, by c-MYC
KJ Wu, A Polack, R Dalla-Favera - Science, 1999 - science.org
KJ Wu, A Polack, R Dalla-Favera
Science, 1999•science.orgThe protein encoded by the c-MYC proto-oncogene is a transcription factor that can both
activate and repress the expression of target genes, but few of its transcriptional targets have
been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the
protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression
of the iron regulatory protein–2 (IRP2), which increases the intracellular iron pool. Down-
regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC …
activate and repress the expression of target genes, but few of its transcriptional targets have
been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the
protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression
of the iron regulatory protein–2 (IRP2), which increases the intracellular iron pool. Down-
regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC …
The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein–2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.
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