[HTML][HTML] Liver kinase B1 suppresses lipopolysaccharide-induced nuclear factor κB (NF-κB) activation in macrophages
Z Liu, W Zhang, M Zhang, H Zhu, C Moriasi… - Journal of Biological …, 2015 - ASBMB
Liver kinase B1 (LKB1), a serine/threonine kinase, is a tumor suppressor and metabolic
regulator. Recent data suggest that LKB1 is essential in regulating homeostasis of
hematopoietic cells and immune responses. However, its role in macrophages and innate
immune system remains unclear. Here we report that macrophage LKB1 inhibits pro-
inflammatory signaling in response to LPS. LPS-induced pro-inflammatory cytokines and pro-
inflammatory enzymes were monitored in bone marrow-derived macrophages isolated from …
regulator. Recent data suggest that LKB1 is essential in regulating homeostasis of
hematopoietic cells and immune responses. However, its role in macrophages and innate
immune system remains unclear. Here we report that macrophage LKB1 inhibits pro-
inflammatory signaling in response to LPS. LPS-induced pro-inflammatory cytokines and pro-
inflammatory enzymes were monitored in bone marrow-derived macrophages isolated from …