Enhancer of zeste homolog 2 inhibition attenuates renal fibrosis by maintaining Smad7 and phosphatase and tensin homolog expression
X Zhou, X Zang, M Ponnusamy… - Journal of the …, 2016 - journals.lww.com
Enhancer of zeste homolog 2 (EZH2) is a methyltransferase that induces histone H3 lysine
27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types.
However, the role of EZH2 in renal fibrogenesis remains unexplored. In this study, we found
high expression of EZH2 and H3K27me3 in cultured renal fibroblasts and fibrotic kidneys
from mice with unilateral ureteral obstruction and humans with CKD. Pharmacologic
inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) or GSK126 or siRNA-mediated …
27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types.
However, the role of EZH2 in renal fibrogenesis remains unexplored. In this study, we found
high expression of EZH2 and H3K27me3 in cultured renal fibroblasts and fibrotic kidneys
from mice with unilateral ureteral obstruction and humans with CKD. Pharmacologic
inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) or GSK126 or siRNA-mediated …