Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase

A Ait-Belgnaoui, S Bradesi, J Fioramonti, V Theodorou… - Pain, 2005 - Elsevier
Hypersensitivity to rectal or colonic distension characterizes most patients with IBS and
increased gut permeability has been described in post-dysenteric IBS patients. However, no
link has been established between these two events. The aim of this study was to determine
(i) whether chemical blockade of stress-induced increase of colonic paracellular
permeability by 2, 4, 6 triaminopyrimidine (TAP) affects the concomitant hypersensitivity to
colonic distension,(ii) the role of epithelial cell contraction in the stress-induced increased …