[HTML][HTML] Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard
YE Chen, DJ Drucker - Journal of Biological Chemistry, 1997 - ASBMB
Glucagon-like peptide 1 stimulates insulin secretion and inhibits glucagon secretion, gastric
emptying, and feeding, suggesting it may be biologically useful for the treatment of diabetes.
A lizard glucagon-like peptide 1 (GLP-1)-related peptide, exendin 4, binds to the GLP-1
receptor and mimics the actions of GLP-1 in vivo To determine the genetic relationship
between exendin 4 and GLP-1, we analyzed the structure and expression of pancreatic and
intestinal proglucagon mRNAs in the reptile Heloderma suspectum Two different …
emptying, and feeding, suggesting it may be biologically useful for the treatment of diabetes.
A lizard glucagon-like peptide 1 (GLP-1)-related peptide, exendin 4, binds to the GLP-1
receptor and mimics the actions of GLP-1 in vivo To determine the genetic relationship
between exendin 4 and GLP-1, we analyzed the structure and expression of pancreatic and
intestinal proglucagon mRNAs in the reptile Heloderma suspectum Two different …