[HTML][HTML] Partial purification and characterization of γ-secretase from post-mortem human brain
MR Farmery, LO Tjernberg, SE Pursglove… - Journal of Biological …, 2003 - ASBMB
One characteristic feature of Alzheimer's disease is the deposition of amyloid β-peptide (Aβ)
as amyloid plaques within specific regions of the human brain. Aβ is derived from the
amyloid β-peptide precursor protein (β-APP) by the intramembranous cleavage activity of γ-
secretase. Studies in cells have revealed that γ-secretase is a large multimeric membrane-
bound protein complex that is functionally dependent on several proteins, including
presenilin, nicastrin, Aph-1, and Pen-2. However, the precise biochemical and molecular …
as amyloid plaques within specific regions of the human brain. Aβ is derived from the
amyloid β-peptide precursor protein (β-APP) by the intramembranous cleavage activity of γ-
secretase. Studies in cells have revealed that γ-secretase is a large multimeric membrane-
bound protein complex that is functionally dependent on several proteins, including
presenilin, nicastrin, Aph-1, and Pen-2. However, the precise biochemical and molecular …