[HTML][HTML] Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
T Lapidot, I Petit - Experimental hematology, 2002 - Elsevier
Mobilization of hematopoietic stem and progenitor cells from the bone marrow into the
circulation by repetitive, daily stimulations with G-CSF alone, or in combination with
cyclophosphamide, is increasingly used clinically; however, the mechanism is not fully
understood. Moreover, following mobilization stem cells also home back to the bone
marrow, suggesting that stem cell release/mobilization and homing are sequential events
with physiological roles. Previously, a role for cytokines such as G-CSF and SCF, and …
circulation by repetitive, daily stimulations with G-CSF alone, or in combination with
cyclophosphamide, is increasingly used clinically; however, the mechanism is not fully
understood. Moreover, following mobilization stem cells also home back to the bone
marrow, suggesting that stem cell release/mobilization and homing are sequential events
with physiological roles. Previously, a role for cytokines such as G-CSF and SCF, and …