Applying synthetic lethality for the selective targeting of cancer

DP McLornan, A List, GJ Mufti - New England Journal of Medicine, 2014 - Mass Medical Soc
New England Journal of Medicine, 2014Mass Medical Soc
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Synthetic lethality refers to the requirement that two defects be present for cell death to occur. When an agent damages DNA, its effects on the cell can be amplified if the efforts of the cell to repair the damage are inhibited. Clinical application of this idea is just beginning.
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