Cadherins are transmembrane receptors that mediate cell-cell adhesion in epithelial cells. A
number of changes occur during cadherin-mediated junction formation, one of which is a
rearrangement of the actin cytoskeleton. Key regulators of actin cytoskeletal dynamics in
cells are the Rho family of GTPases. We have demonstrated in previous studies that
cadherin signaling suppresses RhoA activity and activates Rac1. The signaling events
downstream of cadherins that modulate the activity of Rho family proteins remain unknown …