NPY, NPY receptors, and DPP IV activity are modulated by LPS, TNF-α and IFN-γ in HUVEC
AP Silva, C Cavadas, B Baı̈sse-Agushi, O Spertini… - Regulatory peptides, 2003 - Elsevier
Since NPY increases endothelial cell (EC) stickiness for leukocytes, we studied the effects of
LPS, TNF-α and IFN-γ on its expression and action in HUVEC. Cytokines raised NPY and
pro-NPY intracellular content and dipeptidyl peptidase IV (DPP IV) activity. Y1 and Y2
receptors were expressed in basal conditions, and LPS, TNF-α and IFN-γ induced Y5
receptor expression with a concomitant extinction of Y2 receptor expression. NPY induced
an intracellular calcium increase mainly mediated by Y2 and Y5 receptors in basal …
LPS, TNF-α and IFN-γ on its expression and action in HUVEC. Cytokines raised NPY and
pro-NPY intracellular content and dipeptidyl peptidase IV (DPP IV) activity. Y1 and Y2
receptors were expressed in basal conditions, and LPS, TNF-α and IFN-γ induced Y5
receptor expression with a concomitant extinction of Y2 receptor expression. NPY induced
an intracellular calcium increase mainly mediated by Y2 and Y5 receptors in basal …