[HTML][HTML] Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV
Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that is constitutively expressed in
most tissues and displayed on the cell surface in association with heparan sulfate (HS). Its
numerous biological effects are mediated by a specific G protein-coupled receptor, CXCR4.
A number of cells inactivate SDF-1 by specific processing of the N-terminal domain of the
chemokine. In particular, CD26/dipeptidyl peptidase IV (DPP IV), a serine protease that co-
distributes with CXCR4 at the cell surface, mediates the selective removal of the N-terminal …
most tissues and displayed on the cell surface in association with heparan sulfate (HS). Its
numerous biological effects are mediated by a specific G protein-coupled receptor, CXCR4.
A number of cells inactivate SDF-1 by specific processing of the N-terminal domain of the
chemokine. In particular, CD26/dipeptidyl peptidase IV (DPP IV), a serine protease that co-
distributes with CXCR4 at the cell surface, mediates the selective removal of the N-terminal …