Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
R Mentlein - Regulatory peptides, 1999 - Elsevier
Dipeptidyl-peptidase IV (DPP IV/CD26) has a dual function as a regulatory protease and as
a binding protein. Its role in the inactivation of bioactive peptides was recognized 20 years
ago due to its unique ability to liberate Xaa–Pro or Xaa–Ala dipeptides from the N-terminus
of regulatory peptides, but further examples are now emerging from in vitro and vivo
experiments. Despite the minimal N-terminal truncation by DPP IV, many mammalian
regulatory peptides are inactivated—either totally or only differentially—for certain receptor …
a binding protein. Its role in the inactivation of bioactive peptides was recognized 20 years
ago due to its unique ability to liberate Xaa–Pro or Xaa–Ala dipeptides from the N-terminus
of regulatory peptides, but further examples are now emerging from in vitro and vivo
experiments. Despite the minimal N-terminal truncation by DPP IV, many mammalian
regulatory peptides are inactivated—either totally or only differentially—for certain receptor …