Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration

WC Gordon, NG Bazan - Current Eye Research, 2013 - Taylor & Francis
WC Gordon, NG Bazan
Current Eye Research, 2013Taylor & Francis
Studies in the central nervous system (CNS) and retina have revealed the significance of
docosahexaenoic acid (DHA), an essential omega-3, 22 carbon 6 double bond (22: 6), fatty
acid. DHA is necessary for various functions in the CNS, including neuronal membrane bio-
and synaptogenesis in memory and vision, and it is the precursor for docosanoids and
neuroprotectin D1 (NPD1; 10R, 17S-dihydroxy-docosa-4Z, 7Z, 11E, 13E, 15Z, 19Z
hexaenoic acid), a DHA bio-derivative with neuroprotective properties. This review covers …
Abstract
Studies in the central nervous system (CNS) and retina have revealed the significance of docosahexaenoic acid (DHA), an essential omega-3, 22 carbon 6 double bond (22:6), fatty acid. DHA is necessary for various functions in the CNS, including neuronal membrane bio- and synaptogenesis in memory and vision, and it is the precursor for docosanoids and neuroprotectin D1 (NPD1; 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z hexaenoic acid), a DHA bio-derivative with neuroprotective properties. This review covers three targets in ophthalmology for mediator lipidomics, a subgroup within the field of metabolomics: inflammation, neuroprotection and nerve regeneration. It also discusses the role DHA, NPD1 and other lipid mediators play in these three areas.
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