[HTML][HTML] Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells
T Kogai, YY Liu, K Mody, DV Shamsian… - Journal of Biological …, 2012 - ASBMB
Activation of p38 MAPK is a key pathway for cell proliferation and differentiation in breast
cancer and thyroid cells. The sodium/iodide symporter (NIS) concentrates iodide in the
thyroid and lactating breast. All-trans-retinoic acid (tRA) markedly induces NIS activity in
some breast cancer cell lines and promotes uptake of β-emitting radioiodide 131 I sufficient
for targeted cytotoxicity. To identify a signal transduction pathway that selectively stimulates
NIS expression, we investigated regulation by the Rac1-p38 signaling pathway in MCF-7 …
cancer and thyroid cells. The sodium/iodide symporter (NIS) concentrates iodide in the
thyroid and lactating breast. All-trans-retinoic acid (tRA) markedly induces NIS activity in
some breast cancer cell lines and promotes uptake of β-emitting radioiodide 131 I sufficient
for targeted cytotoxicity. To identify a signal transduction pathway that selectively stimulates
NIS expression, we investigated regulation by the Rac1-p38 signaling pathway in MCF-7 …