Requirement of transcription factor PU. 1 in the development of multiple hematopoietic lineages
The transcription factor PU. 1 is a hematopoietic-specific member of the ets family. Mice
carrying a mutation in the PU. 1 locus were generated by gene targeting. Homozygous
mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers
of megakaryocytes and erythroid progenitors, but some showed an impairment of
erythroblast maturation. An invariant consequence of the mutation was a multilineage defect
in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes …
carrying a mutation in the PU. 1 locus were generated by gene targeting. Homozygous
mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers
of megakaryocytes and erythroid progenitors, but some showed an impairment of
erythroblast maturation. An invariant consequence of the mutation was a multilineage defect
in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes …
The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor.
AAAS