[HTML][HTML] Platelet apoptosis by cold‐induced glycoprotein Ibα clustering
DE van der Wal, VX Du, KSL Lo, JT Rasmussen… - Journal of Thrombosis …, 2010 - Elsevier
Background: Cold‐storage of platelets followed by rewarming induces changes in
Glycoprotein (GP) Ibα‐distribution indicative of receptor clustering and initiates thromboxane
A 2‐formation. GPIbα is associated with 14‐3‐3 proteins, which contribute to GPIbα‐
signaling and in nucleated cells take part in apoptosis regulation. Objectives and methods:
We investigated whether GPIbα‐clustering induces platelet apoptosis through 14‐3‐3
proteins during cold (4 h 0° C)‐rewarming (1 h 37° C). Results: During cold‐rewarming, 14 …
Glycoprotein (GP) Ibα‐distribution indicative of receptor clustering and initiates thromboxane
A 2‐formation. GPIbα is associated with 14‐3‐3 proteins, which contribute to GPIbα‐
signaling and in nucleated cells take part in apoptosis regulation. Objectives and methods:
We investigated whether GPIbα‐clustering induces platelet apoptosis through 14‐3‐3
proteins during cold (4 h 0° C)‐rewarming (1 h 37° C). Results: During cold‐rewarming, 14 …