[HTML][HTML] Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques
C Moog, N Dereuddre-Bosquet, JL Teillaud… - Mucosal …, 2014 - Elsevier
Definition of antibody (Ab) functions capable of preventing mucosal HIV transmission may
be critical to both effective vaccine development and the prophylactic use of monoclonal
Abs. Although direct antibody-mediated neutralization is highly effective against cell-free
virus, increasing evidence suggests an important role for immunoglobulin G (IgG) Fcγ
receptor (FcγR)–mediated inhibition of HIV replication. Thus, a panel of well-known
neutralizing (NAbs) and nonneutralizing Abs (NoNAbs) were screened for their ability to …
be critical to both effective vaccine development and the prophylactic use of monoclonal
Abs. Although direct antibody-mediated neutralization is highly effective against cell-free
virus, increasing evidence suggests an important role for immunoglobulin G (IgG) Fcγ
receptor (FcγR)–mediated inhibition of HIV replication. Thus, a panel of well-known
neutralizing (NAbs) and nonneutralizing Abs (NoNAbs) were screened for their ability to …