Reduced GABA concentration in attention-deficit/hyperactivity disorder
Context Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder
characterized by a deficit in behavioral inhibition. Recent evidence also suggests a deficit in
cortical inhibition via the GABA (γ-aminobutyric acid)–ergic system. Objective To investigate
the GABAergic component of ADHD using magnetic resonance spectroscopy. Design Cross-
sectional study. Setting Participants were recruited through local schools, local pediatric and
other community clinics, and through advertisement in regional publications. Magnetic …
characterized by a deficit in behavioral inhibition. Recent evidence also suggests a deficit in
cortical inhibition via the GABA (γ-aminobutyric acid)–ergic system. Objective To investigate
the GABAergic component of ADHD using magnetic resonance spectroscopy. Design Cross-
sectional study. Setting Participants were recruited through local schools, local pediatric and
other community clinics, and through advertisement in regional publications. Magnetic …