Nephrotic syndrome is a CKD defined by proteinuria with subsequent hypoalbuminemia,
hyperlipidemia, and edema caused by impaired renal glomerular filtration barrier function.
We previously identified mutations in epithelial membrane protein 2 (EMP2) as a monogenic
cause of this disease. Here, we generated an emp2-knockout zebrafish model using
transcription activator-like effector nuclease–based genome editing. We found that loss of
emp2 in zebrafish upregulated caveolin-1 (cav1), a major component of caveolae, in …