[HTML][HTML] Regulation of a novel human phospholipase C, PLCε, through membrane targeting by Ras

C Song, CD Hu, M Masago, K Kariya… - Journal of Biological …, 2001 - ASBMB
Phosphoinositide-specific phospholipase C (PI-PLC) plays a pivotal role in regulation of
intracellular signal transduction from various receptor molecules. More than 10 members of
human PI-PLC isoforms have been identified and classified into three classes β, γ, and δ,
which are regulated by distinct mechanisms. Here we report identification of a novel class of
human PI-PLC, named PLCε, which is characterized by the presence of a Ras-associating
domain at its C terminus and a CDC25-like domain at its N terminus. The Ras-associating …