[HTML][HTML] De novo donor-specific HLA antibodies are associated with rapid loss of graft function following islet transplantation in type 1 diabetes
AMS Brooks, V Carter, A Liew, H Marshall… - American Journal of …, 2015 - Elsevier
Outcomes after islet transplantation continue to improve but etiology of graft failure remains
unclear. De novo donor-specific human leukocyte antigen (HLA) antibodies (DSA)
posttransplant are increasingly recognized as a negative prognostic marker. Specific
temporal associations between DSA and graft function remain undefined particularly in
programs undertaking multiple sequential transplants. Impact of de novo DSA on graft
function over 12 months following first islet transplant was determined prospectively in …
unclear. De novo donor-specific human leukocyte antigen (HLA) antibodies (DSA)
posttransplant are increasingly recognized as a negative prognostic marker. Specific
temporal associations between DSA and graft function remain undefined particularly in
programs undertaking multiple sequential transplants. Impact of de novo DSA on graft
function over 12 months following first islet transplant was determined prospectively in …