Acyl-coenzyme A thioesterases (Acots) play important cellular roles in mammalian fatty acid
metabolism through modulation of cellular concentrations of activated fatty acyl-CoAs. Acots
catalyse the hydrolysis of the thioester bond present within acyl-CoA ester molecules to yield
coenzyme A (CoASH) and the corresponding non-esterified fatty acid. Acyl-CoA
thioesterases are expressed ubiquitously in both prokaryotes and eukaryotes and, in higher
order organisms, the enzymes are expressed and localised in a tissue-dependent manner …