[HTML][HTML] Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality
AB Francisco, R Singh, S Li, AK Vani, L Yang… - Journal of biological …, 2010 - ASBMB
Stress in the endoplasmic reticulum (ER) plays an important causal role in the pathogenesis
of several chronic diseases such as Alzheimer, Parkinson, and diabetes mellitus. Insight into
the genetic determinants responsible for ER homeostasis will greatly facilitate the
development of therapeutic strategies for the treatment of these debilitating diseases.
Suppressor enhancer Lin12 1 like (SEL1L) is an ER membrane protein and was thought to
be involved in the quality control of secreted proteins. Here we show that the mice …
of several chronic diseases such as Alzheimer, Parkinson, and diabetes mellitus. Insight into
the genetic determinants responsible for ER homeostasis will greatly facilitate the
development of therapeutic strategies for the treatment of these debilitating diseases.
Suppressor enhancer Lin12 1 like (SEL1L) is an ER membrane protein and was thought to
be involved in the quality control of secreted proteins. Here we show that the mice …