Viral infections in interferon-γ receptor deficiency

SE Dorman, G Uzel, J Roesler, JS Bradley… - The Journal of …, 1999 - Elsevier
SE Dorman, G Uzel, J Roesler, JS Bradley, J Bastian, G Billman, S King, A Filie…
The Journal of pediatrics, 1999Elsevier
Interferon-γ receptor deficiency is a recently described immunodeficiency that is associated
with onset of severe mycobacterial infections in childhood. We describe the occurrence of
symptomatic and often severe viral infections in 4 patients with interferon-γ receptor
deficiency and mycobacterial disease. The viral pathogens included herpes viruses,
parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with
interferon-γ receptor deficiency and mycobacterial disease have increased susceptibility to …
Interferon-γ receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-γ receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-γ receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens. (J Pediatr 1999;135:640-3)
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