[HTML][HTML] Phosphatidylinositol (4, 5)-bisphosphate-dependent activation of dynamins I and II lacking the proline/arginine-rich domains

HC Lin, B Barylko, M Achiriloaie, JP Albanesi - Journal of Biological …, 1997 - ASBMB
Dynamins comprise a family of GTPases that participate in the early stages of endocytosis.
The GTPase activity of neuronal specific dynamin I is stimulated by microtubules, negatively
charged phospholipid vesicles, and Src homology 3-containing proteins, including Grb2.
These activators were previously shown to bind to a proline/arginine-rich domain (PRD) in
the carboxyl-terminal region of the enzyme. Dynamin II, which is ubiquitously expressed,
had not been purified or characterized previously. In this study, the enzymatic properties of …