IL-25 and CD4+ TH2 cells enhance type 2 innate lymphoid cell–derived IL-13 production, which promotes IgE-mediated experimental food allergy
JB Lee, CY Chen, B Liu, L Mugge… - Journal of Allergy and …, 2016 - Elsevier
Background Food-mediated allergic reactions have emerged as a major health problem.
The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary
allergens in the gastrointestinal tract remain elusive. Objective We investigated whether
altering IL-25 signaling enhances or attenuates allergic responses to food allergens.
Methods Mice of an IL-25 transgenic mouse line (iIL-25Tg mice), which constitutively
overexpress intestinal IL-25, and Il17rb−/− mice, in which Il17rb gene expression is …
The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary
allergens in the gastrointestinal tract remain elusive. Objective We investigated whether
altering IL-25 signaling enhances or attenuates allergic responses to food allergens.
Methods Mice of an IL-25 transgenic mouse line (iIL-25Tg mice), which constitutively
overexpress intestinal IL-25, and Il17rb−/− mice, in which Il17rb gene expression is …