Mechanisms of allergen-specific desensitization
C Uermösi, RR Beerli, M Bauer, V Manolova… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: Allergen-specific desensitization (SIT) is the most effective therapy for
allergies. Although allergen-specific antibodies have an important role in the process,
mechanisms of IgG-mediated inhibition of allergic reactions are not well defined.
OBJECTIVE: We investigated mechanisms by which SIT-induced allergen-specific IgGs
inhibit allergic reactions. METHODS: We generated mAbs that recognize 3 nonoverlapping
epitopes of the major cat allergen Fel d 1. Each of the mAbs was produced as an IgE and …
allergies. Although allergen-specific antibodies have an important role in the process,
mechanisms of IgG-mediated inhibition of allergic reactions are not well defined.
OBJECTIVE: We investigated mechanisms by which SIT-induced allergen-specific IgGs
inhibit allergic reactions. METHODS: We generated mAbs that recognize 3 nonoverlapping
epitopes of the major cat allergen Fel d 1. Each of the mAbs was produced as an IgE and …