[HTML][HTML] Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
M Stanciu, Y Wang, R Kentor, N Burke… - Journal of Biological …, 2000 - ASBMB
Oxidative stress can trigger neuronal cell death and has been implicated in several chronic
neurological diseases and in acute neurological injury. Oxidative toxicity can be induced by
glutamate treatment in cells that lack ionotrophic glutamate receptors, such as the
immortalized HT22 hippocampal cell line and immature primary cortical neurons. Previously,
we found that neuroprotective effects of geldanamycin, a benzoquinone ansamycin, in HT22
cells were associated with a down-regulation of c-Raf-1, an upstream activator of the …
neurological diseases and in acute neurological injury. Oxidative toxicity can be induced by
glutamate treatment in cells that lack ionotrophic glutamate receptors, such as the
immortalized HT22 hippocampal cell line and immature primary cortical neurons. Previously,
we found that neuroprotective effects of geldanamycin, a benzoquinone ansamycin, in HT22
cells were associated with a down-regulation of c-Raf-1, an upstream activator of the …