Nonalcoholic fatty liver disease: a systematic review

ME Rinella - Jama, 2015 - jamanetwork.com
Importance Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis
affect approximately 30% and 5%, respectively, of the US population. In patients with
nonalcoholic steatohepatitis, half of deaths are due to cardiovascular disease and
malignancy, yet awareness of this remains low. Cirrhosis, the third leading cause of death in
patients with nonalcoholic fatty liver disease, is predicted to become the most common
indication for liver transplantation. Objectives To illustrate how to identify patients with …