[HTML][HTML] Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin: A MASS SPECTROMETRIC STUDY (∗)
GN Hendy, HPJ Bennett, BF Gibbs, C Lazure… - Journal of Biological …, 1995 - ASBMB
Parathyroid hormone (PTH), an 84-amino acid peptide, is the major regulator of blood
calcium homeostasis. Its mRNA, in addition to encoding the mature peptide, also encodes a"
pre" sequence of 25 amino acids and a basic" pro" hexapeptide. To assess which of the
subtilisin-like prohormone convertases can process proPTH to PTH we coinfected cells with
a vaccinia virus construct expressing human preproPTH and vaccinia virus constructs
expressing furin, PC1 or PC2. BSC-40 cells, having a constitutive secretory pathway, and …
calcium homeostasis. Its mRNA, in addition to encoding the mature peptide, also encodes a"
pre" sequence of 25 amino acids and a basic" pro" hexapeptide. To assess which of the
subtilisin-like prohormone convertases can process proPTH to PTH we coinfected cells with
a vaccinia virus construct expressing human preproPTH and vaccinia virus constructs
expressing furin, PC1 or PC2. BSC-40 cells, having a constitutive secretory pathway, and …