[HTML][HTML] Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver

SV Shewale, E Boudyguina, X Zhu, L Shen… - Journal of lipid …, 2015 - ASBMB
Echium oil (EO), which is enriched in 18: 4 n-3, the immediate product of fatty acid
desaturase 2 (FADS2) desaturation of 18: 3 n-3, is as atheroprotective as fish oil (FO). The
objective of this study was to determine whether botanical oils enriched in the FADS2
products 18: 3 n-6 versus 18: 4 n-3 are equally atheroprotective. LDL receptor KO mice were
fed one of four atherogenic diets containing 0.2% cholesterol and 10% calories as palm oil
(PO) plus 10% calories as: 1) PO; 2) borage oil (BO; 18: 3 n-6 enriched); 3) EO (18: 4 n-3 …