[HTML][HTML] Lipid activation of CTP: phosphocholine cytidylyltransferase is regulated by the phosphorylated carboxyl-terminal domain
W Yang, S Jackowski - Journal of Biological Chemistry, 1995 - ASBMB
The role of the phosphorylated carboxyl-terminal domain of CTP: phosphocholine
cytidylyltransferase (CT) in the regulation of enzyme activity was investigated by comparing
the catalytic properties of wild-type CT to two mutant proteins with altered carboxyl-terminal
phosphorylation domains. CT isolated from a baculovirus expression system was
extensively phosphorylated at multiple sites in the carboxyl-terminal domain. The CT
[S315A] mutant lacked a major CT phosphorylation site, and the carboxyl-terminal deletion …
cytidylyltransferase (CT) in the regulation of enzyme activity was investigated by comparing
the catalytic properties of wild-type CT to two mutant proteins with altered carboxyl-terminal
phosphorylation domains. CT isolated from a baculovirus expression system was
extensively phosphorylated at multiple sites in the carboxyl-terminal domain. The CT
[S315A] mutant lacked a major CT phosphorylation site, and the carboxyl-terminal deletion …