[HTML][HTML] Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse
JE Hunt, RL Stevens, KF Austen, J Zhang, Z Xia… - Journal of Biological …, 1996 - ASBMB
The C57BL/6 mouse differs from the BALB/c mouse in that its ear and skin mast cells and its
progenitor bone marrow-derived mast cells (mBMMCs) do not express mouse mast cell
protease (mMCP) 7. We now report that, as detected by nuclear run-on analysis, the mMCP-
7 gene is transcribed in C57BL/6 mBMMCs at a rate comparable to that in BALB/c mBMMCs.
Reverse transcriptase-polymerase chain reaction analysis and sequencing of the product
revealed that the ears of C57BL/6 mice contain small amounts of a mMCP-7 transcript that …
progenitor bone marrow-derived mast cells (mBMMCs) do not express mouse mast cell
protease (mMCP) 7. We now report that, as detected by nuclear run-on analysis, the mMCP-
7 gene is transcribed in C57BL/6 mBMMCs at a rate comparable to that in BALB/c mBMMCs.
Reverse transcriptase-polymerase chain reaction analysis and sequencing of the product
revealed that the ears of C57BL/6 mice contain small amounts of a mMCP-7 transcript that …