Regulation and role of brain calcium/calmodulin-dependent protein kinase II
RJ Colbran - Neurochemistry international, 1992 - Elsevier
Abstract Ca 2+/calmodulin-dependent protein kinase II (CaMKII) exhibits a broad substrate
specificity and regulates diverse responses to physiological changes of intracellular Ca 2+
concentrations. Five isozymic subunits of the highly abundant brain kinase are encoded by
four distinct genes. Expression of each gene is tightly regulated in a cell-specific and
developmental manner. CaMKII immunoreactivity is broadly distributed within neurons but is
discretely associated with a number of subcellular structures. The unique regulatory …
specificity and regulates diverse responses to physiological changes of intracellular Ca 2+
concentrations. Five isozymic subunits of the highly abundant brain kinase are encoded by
four distinct genes. Expression of each gene is tightly regulated in a cell-specific and
developmental manner. CaMKII immunoreactivity is broadly distributed within neurons but is
discretely associated with a number of subcellular structures. The unique regulatory …