Activating signals dominate inhibitory signals in CD137L/IL-15 activated natural killer cells
H Zhang, Y Cui, N Voong, M Sabatino… - Journal of …, 2011 - journals.lww.com
Natural killer (NK) cells can mediate potent antitumor effects, but factors regulating the
efficiency of tumor lysis remain unclear. Studies in allogeneic stem cell transplantation
highlight an important role for killer cell immunoglobulin-like receptor (KIR) mismatch in
overcoming human leukocyte antigen-mediated inhibitory signals. However, other activating
and inhibitory signals also modulate tumor lysis by NK cells. We used rhIL15 and artificial
antigen presenting cells expressing CD137L and IL15Rα to activate and expand peripheral …
efficiency of tumor lysis remain unclear. Studies in allogeneic stem cell transplantation
highlight an important role for killer cell immunoglobulin-like receptor (KIR) mismatch in
overcoming human leukocyte antigen-mediated inhibitory signals. However, other activating
and inhibitory signals also modulate tumor lysis by NK cells. We used rhIL15 and artificial
antigen presenting cells expressing CD137L and IL15Rα to activate and expand peripheral …