Role of interleukin-10 in the pathogenesis of necrotizing enterocolitis
BACKGROUND: Necrotizing enterocolitis (NEC) is the most common gastrointestinal
emergency in premature neonates. The pathogenesis of NEC is characterized by an
intestinal epithelial injury caused by perinatal insults, leading to the activation of the mucosal
innate immune system and exacerbation of the epithelial barrier damage. Cytokines play an
important role in mucosal immunity. Interleukin-10 (IL-10) is an anti-inflammatory cytokine
that has been shown to play a role in epithelial integrity and modulation of the mucosal …
emergency in premature neonates. The pathogenesis of NEC is characterized by an
intestinal epithelial injury caused by perinatal insults, leading to the activation of the mucosal
innate immune system and exacerbation of the epithelial barrier damage. Cytokines play an
important role in mucosal immunity. Interleukin-10 (IL-10) is an anti-inflammatory cytokine
that has been shown to play a role in epithelial integrity and modulation of the mucosal …