[HTML][HTML] IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology
Abstract Interleukin-23 (IL-23) responsive group 3 innate lymphoid cells (ILC3s) have been
implicated in immune homeostasis and pathogenesis in the adult, but little is known about
their roles in the newborn. Here we show that IL-23 promotes conversion of embryonic
intestinal Lin− IL-23R+ Thy1+ cells into IL-22-producing Thy1+ Sca-1 hi ILC3s in vitro. Gut-
specific expression of IL-23 also activated and expanded Thy1+ Sca-1 hi ILC3s, which
produced IL-22, IL-17, interferon gamma (IFN-γ), and granulocyte-macrophage colony …
implicated in immune homeostasis and pathogenesis in the adult, but little is known about
their roles in the newborn. Here we show that IL-23 promotes conversion of embryonic
intestinal Lin− IL-23R+ Thy1+ cells into IL-22-producing Thy1+ Sca-1 hi ILC3s in vitro. Gut-
specific expression of IL-23 also activated and expanded Thy1+ Sca-1 hi ILC3s, which
produced IL-22, IL-17, interferon gamma (IFN-γ), and granulocyte-macrophage colony …