[HTML][HTML] Toll-like receptor 2 and DC-SIGNR1 differentially regulate suppressors of cytokine signaling 1 in dendritic cells during Mycobacterium tuberculosis infection
V Srivastava, M Manchanda, S Gupta, R Singla… - Journal of biological …, 2009 - ASBMB
A hallmark of protective immunity during Mycobacterium tuberculosis (M. tb) infection is the
regulated secretion of pro-inflammatory and regulatory cytokines. Suppressors of Cytokine
Signaling (SOCS) are key regulators of cytokine secretion and function. In this study we
investigated regulation of Toll-like receptor 2 (TLR2) and dendritic cell-specific ICAM-3
grabbing non-integrin receptor 1 (DC-SIGNR1)-mediated SOCS1 expression in DCs during
M. tb infection. We show that, compared with TLR2, stimulating DC-SIGNR1 on DCs induces …
regulated secretion of pro-inflammatory and regulatory cytokines. Suppressors of Cytokine
Signaling (SOCS) are key regulators of cytokine secretion and function. In this study we
investigated regulation of Toll-like receptor 2 (TLR2) and dendritic cell-specific ICAM-3
grabbing non-integrin receptor 1 (DC-SIGNR1)-mediated SOCS1 expression in DCs during
M. tb infection. We show that, compared with TLR2, stimulating DC-SIGNR1 on DCs induces …