Persistence of T-cell clones in psoriatic lesions

JCC Chang, LR Smith, KJ Froning… - Archives of …, 1997 - jamanetwork.com
Background: We previously demonstrated a clonal dominance in the Vβ13. 1 messages
isolated from the lesional CD8+ T cells of psoriasis vulgaris, which suggested an interaction
of Vβ13. 1+ CD8+ T cells with skin antigens. Objectives: To determine whether the clonality
observed accurately reflected a clonal population of infiltrating T cells or was skewed by an
overabundance of messages from a small number of cells, and to extend our study of Vβ
gene usage by lesional CD8+ T cells to 9 new patients. Design: Case study. Setting …