Rocks: multifunctional kinases in cell behaviour

K Riento, AJ Ridley - Nature reviews Molecular cell biology, 2003 - nature.com
K Riento, AJ Ridley
Nature reviews Molecular cell biology, 2003nature.com
ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of
cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent
experiments have defined new functions of ROCKs in cells, including centrosome
positioning and cell-size regulation, which might contribute to various physiological and
pathological states.
Abstract
ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.
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