Multicenter randomized controlled trial of bacterial interference for prevention of urinary tract infection in patients with neurogenic bladder

RO Darouiche, BG Green, WH Donovan, D Chen… - Urology, 2011 - Elsevier
OBJECTIVES: To compare the effectiveness of bacterial interference versus placebo in
preventing urinary tract infection (UTI). METHODS: The main outcome measure was the
numbers of episodes of UTI/patient-year. Randomization was computer generated, with
allocation concealment by visibly indistinguishable products distributed from a core facility.
The healthcare providers and those assessing the outcomes were unaware of the group
allocation. Adult patients (n= 65) with neurogenic bladder after spinal cord injury and a …