Decreased microbiota diversity associated with urinary tract infection in a trial of bacterial interference
Background Patients with long-term indwelling catheters are at high risk of catheter-
associated urinary tract infection (CAUTI). We hypothesized that colonizing the bladder with
a benign Escherichia coli strain (E. coli HU2117, a derivative of E. coli 83972) would prevent
CAUTI in older, catheterized adults. Materials and methods Adults with chronic, indwelling
urinary catheters received study catheters that had been pre-coated with E. coli HU2117. We
monitored the cultivatable organisms in the bladder for 28 days or until loss of E. coli …
associated urinary tract infection (CAUTI). We hypothesized that colonizing the bladder with
a benign Escherichia coli strain (E. coli HU2117, a derivative of E. coli 83972) would prevent
CAUTI in older, catheterized adults. Materials and methods Adults with chronic, indwelling
urinary catheters received study catheters that had been pre-coated with E. coli HU2117. We
monitored the cultivatable organisms in the bladder for 28 days or until loss of E. coli …