Heterotrimeric G protein activation by G-protein-coupled receptors
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction
pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these
receptors, which then catalyse GTP–GDP exchange on the G protein α-subunit. The
complex series of interactions and conformational changes that connect agonist binding to G
protein activation raise various interesting questions about the structure, biomechanics,
kinetics and specificity of signal transduction across the plasma membrane.
pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these
receptors, which then catalyse GTP–GDP exchange on the G protein α-subunit. The
complex series of interactions and conformational changes that connect agonist binding to G
protein activation raise various interesting questions about the structure, biomechanics,
kinetics and specificity of signal transduction across the plasma membrane.
Abstract
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP–GDP exchange on the G protein α-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane.
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