[PDF][PDF] A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

AA Aravin, R Sachidanandam, D Bourc'his, C Schaefer… - Molecular cell, 2008 - cell.com
AA Aravin, R Sachidanandam, D Bourc'his, C Schaefer, D Pezic, KF Toth, T Bestor
Molecular cell, 2008cell.com
Summary piRNAs and Piwi proteins have been implicated in transposon control and are
linked to transposon methylation in mammals. Here we examined the construction of the
piRNA system in the restricted developmental window in which methylation patterns are set
during mammalian embryogenesis. We find robust expression of two Piwi family proteins,
MIWI2 and MILI. Their associated piRNA profiles reveal differences from Drosophila wherein
large piRNA clusters act as master regulators of silencing. Instead, in mammals, dispersed …
Summary
piRNAs and Piwi proteins have been implicated in transposon control and are linked to transposon methylation in mammals. Here we examined the construction of the piRNA system in the restricted developmental window in which methylation patterns are set during mammalian embryogenesis. We find robust expression of two Piwi family proteins, MIWI2 and MILI. Their associated piRNA profiles reveal differences from Drosophila wherein large piRNA clusters act as master regulators of silencing. Instead, in mammals, dispersed transposon copies initiate the pathway, producing primary piRNAs, which predominantly join MILI in the cytoplasm. MIWI2, whose nuclear localization and association with piRNAs depend upon MILI, is enriched for secondary piRNAs antisense to the elements that it controls. The Piwi pathway lies upstream of known mediators of DNA methylation, since piRNAs are still produced in dnmt3L mutants, which fail to methylate transposons. This implicates piRNAs as specificity determinants of DNA methylation in germ cells.
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