Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer
AR Bauskin, DA Brown, T Kuffner, H Johnen, XW Luo… - Cancer research, 2006 - AACR
Abstract Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-β
superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used
as a clinical tool for the diagnosis and management of a wide range of cancers. Although
generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion,
processing, and latent storage suggest a complex, dynamic variability in MIC-1
bioavailability in the tumor microenvironment, potentially modulating tumor progression and …
superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used
as a clinical tool for the diagnosis and management of a wide range of cancers. Although
generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion,
processing, and latent storage suggest a complex, dynamic variability in MIC-1
bioavailability in the tumor microenvironment, potentially modulating tumor progression and …
Abstract
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-β superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness. (Cancer Res 2006; 66(10): 4983-5)
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