Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells
PM Ejercito, ED Kieff… - Journal of General …, 1968 - microbiologyresearch.org
PM Ejercito, ED Kieff, B Roizman
Journal of General Virology, 1968•microbiologyresearch.orgEstablished (laboratory) strains and fresh isolates of herpes simplex virus from patients with
skin and genital lesions were classified into four groups depending on their effects on the
social interaction among infected hep-2 cells. The groups comprised strains causing (1)
rounding of cells but no adhesion or fusion,(2) loose aggregation of rounded cells,(3) tight
adhesion of rounded cells, and (4) fusion of cells into polykaryocytes. Protype strains from
each group were found to differ with respect to immunologic specificity, buoyant density in …
skin and genital lesions were classified into four groups depending on their effects on the
social interaction among infected hep-2 cells. The groups comprised strains causing (1)
rounding of cells but no adhesion or fusion,(2) loose aggregation of rounded cells,(3) tight
adhesion of rounded cells, and (4) fusion of cells into polykaryocytes. Protype strains from
each group were found to differ with respect to immunologic specificity, buoyant density in …
Summary
Established (laboratory) strains and fresh isolates of herpes simplex virus from patients with skin and genital lesions were classified into four groups depending on their effects on the social interaction among infected hep-2 cells. The groups comprised strains causing (1) rounding of cells but no adhesion or fusion, (2) loose aggregation of rounded cells, (3) tight adhesion of rounded cells, and (4) fusion of cells into polykaryocytes. Protype strains from each group were found to differ with respect to immunologic specificity, buoyant density in CsCl solutions and stability at 4°.
Microbiology Research